Isopto Carpine

Pilocarpine Hydrochloride Ophthalmic Solution 2%: Miotic and Cholinergic Agent

Pilocarpine Hydrochloride Ophthalmic Solution is a topical Cholinergic medication used in veterinary medicine primarily for its Miotic (pupil-constricting) properties. While originally approved for human use, it is utilized by veterinarians on an extra-label basis for dogs and cats. Pilocarpine works by stimulating the cholinergic receptors in the eye, which causes the iris sphincter muscle to contract (constricting the pupil) and improves the outflow of aqueous humor to help manage certain types of glaucoma. It is also used diagnostically and therapeutically in the management of "Dry Eye" (neurogenic keratoconjunctivitis sicca) by stimulating tear production when administered orally under strict guidance.

Key Information

• Active Ingredient: Pilocarpine Hydrochloride (2%).

• Approved Species (Original Licensing): Human.

• Common Veterinary Species: Dog and Cat (used extra-label).

• Uses: Miotic and Cholinergic (used to treat primary glaucoma and as a diagnostic/treatment aid for neurogenic dry eye).

• Form: Liquid / Ophthalmic Solution (preserved with benzalkonium chloride).

• Route of Administration: Ophthalmic (Eye Drops).

Prescription Required

Pilocarpine Hydrochloride is a prescription-only medication. A valid prescription from a licensed veterinarian is required for purchase. Professional oversight is critical as this medication can cause significant ocular irritation, redness, and discomfort. Because it constricts the pupil, it is generally avoided in cases of secondary glaucoma caused by uveitis (inflammation). Your veterinarian must monitor your pet’s intraocular pressure and ocular comfort closely to ensure the medication is providing the desired therapeutic benefit without causing adverse effects.