Apo-Azathioprine

APO-Azathioprine Tablets (50 mg): Potent Immunosuppressant

Azathioprine is a powerful Immunosuppressant medication (though sometimes categorized as an immunomodulator). While originally approved for human use, it is a critical medication in veterinary medicine used on an extra-label basis, primarily in dogs. It works by interfering with DNA synthesis in rapidly dividing cells, specifically targeting the production of T and B lymphocytes. This helps to quiet the overactive immune response responsible for various autoimmune and inflammatory diseases.

Key Information

• Active Ingredient: Azathioprine (50 mg).

• Approved Species (Original Licensing): Human.

• Common Veterinary Species: Dog (used extra-label).

• Uses: Treatment of severe immune-mediated conditions such as Immune-Mediated Hemolytic Anemia (IMHA), Immune-Mediated Thrombocytopenia (ITP), severe inflammatory bowel disease (IBD), and certain autoimmune skin diseases (e.g., Pemphigus).

• Form: Pale yellow, peanut-shaped tablet, scored and engraved "AZ 50" and "APO".

• Route of Administration: Oral.

Prescription Required

Azathioprine is a prescription-only medication. A valid prescription from a licensed veterinarian is required for purchase. Professional oversight is essential as this medication can have a narrow safety margin.

Critical Safety Warnings:

• Do Not Use in Cats: Azathioprine is highly toxic to cats. They lack the necessary enzyme to metabolize the drug properly, which can lead to life-threatening or fatal bone marrow suppression.

• Bone Marrow Monitoring: In dogs, this drug can cause a drop in white blood cell counts and platelets. Regular blood work (CBC) is mandatory to monitor for bone marrow suppression and liver toxicity.

• Handling: Because this is a cytotoxic drug, pet owners should wear gloves when handling the tablets and should not crush or break them. Pregnant individuals should avoid contact with the medication.