Anafranil

Anafranil Tablets (10 mg, 25 mg, 50 mg): Tricyclic Antidepressant for Anxiety Disorders

Anafranil contains Clomipramine hydrochloride, a tricyclic antidepressant (TCA). While these specific tablets are originally approved for human use, Clomipramine is widely used in veterinary medicine on an extra-label basis for dogs and cats. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps to regulate mood and emotional response. In pets, it is primarily prescribed to manage complex behavioral issues related to anxiety and compulsive disorders.

Key Information

• Active Ingredient: Clomipramine hydrochloride.

• Approved Species (Original Licensing): Human.

• Common Veterinary Species: Dog and Cat (used extra-label).

• Uses: Treatment of separation anxiety, obsessive-compulsive disorders (e.g., tail-chasing or excessive licking), and feline inappropriate urination (spraying).

• Form:

  • 10 mg: Pale yellow, triangular tablet, engraved "10" and "CP".

  • 25 mg: Pale yellow, round tablet, engraved "25" and "CP".

  • 50 mg: White, round tablet, engraved "CP 50".

• Route of Administration: Oral.

Prescription Required

Anafranil is a prescription-only medication. A valid prescription from a licensed veterinarian is required for purchase. Professional supervision is essential because Clomipramine can take several weeks to reach full therapeutic effect and requires careful dose adjustment. It should not be used in pets with certain heart conditions or those currently taking MAO inhibitors (like selegiline). Your veterinarian will monitor your pet for potential side effects, such as lethargy or dry mouth, and will guide you on how to safely taper the medication if it needs to be discontinued.